Endocrine Abstracts

A 51 year old female presented with an Adjusted Calcium (Adj Cal) of 1.68mmol/l (Ref: 2.20-2.60 mmol/l), raised PTH 24.2 pmol/l (1.6-6.9 pmol/l) and raised Alkaline phosphatase (ALP). She had a background of type 2 intestinal failure secondary to surgical complications resulting in stoma formation. She reported peri-oral tingling, joint stiffness, cramps and generalised pain over several months which left her requiring the use of a wheelchair for mobilisation. There was proxim...

Objectives: Hypophosphatasia (HPP) is a rare genetic disorder. Early diagnosis is challenging due to the disease’s complexity and low physician awareness.1 This study aimed to demonstrate how a digital health approach that scans electronic health records (EHR) may lead to earlier diagnosis of HPP.Methods: Patients with HPP were identified in the Optimum Patient Care Research Database (OPCRD), a UK database of 13.7 m...

Background: Idiopathic Hypogonadotropic Hypogonadism (IHH) is a condition caused by deficiency or insensitivity to gonadotropin-releasing hormone where the pathology behind the mechanism is unknown and no secondary causes of hypogonadotropic hypogonadism are present. The condition not only effect sexual characteristic but can affect the physical and psychosocial development of a patient therefore making its prompt diagnoses and treatment necessary. The purpose of this study wa...

Objective: To study association of endometrial thickness measured on ovulation induction (OI) day with cycle outcome after ICSI.Subjects and methods: It was a quasi experimental design carried out in an infertility clinic from July 2011 till June 2012. The treatment comprised of down regulation of ovaries, controlled ovarian stimulation, oocyte pick up, IVF, embryo (blastocysts) transfer followed by confirmation of pregnancy with beta hCG more than 25 mI...

Acute fatty liver of pregnancy (AFLP) is a rare obstetric metabolic emergency (UK incidence 1/20.000 maternities) which typically presents in 3rd trimester or postpartum and has a high maternal and foetal mortality and morbidity (UK Maternal mortality 1.8%, perinatal mortality 104/1000 births). Diagnosis can be delayed due to lack of set diagnostic criteria, rarity and overlapping clinical presentation with many other obstetric metabolic pathologies. Urgent delivery...

Section 1: A 77 year female was referred by her GP in May 2019 for abnormal thyroid function tests (TFT) which were requested due to new diagnosis of atrial fibrillation. The patient was otherwise asymptomatic and clinically euthyroid. Family History was negative for thyroid abnormalities. On enquiry, the patient revealed that she had abnormal thyroid function tests associated with a large goitre in 1970s and subsequently underwent partial thyroidectomy followed by radioactive...

Aim: This is a retrospective study of imaging with adrenal incidentalomas at our DGH to assess clinical practice. Their management was followed and compared with the European Society of Endocrinology (ESE) Clinical Practice Guidelines 2016 for management of adrenal incidentalomas. The aim was to improve clinical service by developing a local management pathway.Materials and Methods: Data was collected for two years from 2018 to 2019 which included all im...

We present a 60-year-old man who was referred to endocrine clinic with fatigue and a random cortisol of 136nmol/l . He had clear renal cell carcinoma and had right radical nephrectomy 7 years ago. Surveillance scans revealed involvement of mediastinal lymph nodes, pancreas and small bowel and he has pancreatic and small bowel resection in four years ago. He had recurrence a year ago and received Ipilimumab and Nivolumab. Biochemistry revealed low fT4 and inappropriately normal...

Autotaxin (ATX) is a secreted enzyme that generates the lipid signalling molecule LPAs from LPCs. The ATX/lPA axis is strongly linked to fibrotic diseases and therapeutic inhibitors are in development. Assessing the balance of LPC/lPA in diseased target tissues is critical to inform pharmacokinetics/pharmacodynamics (PK-PD) and predict efficacy of ATX inhibitors in vivo. Mass spectrometry imaging (MSI) allows concomitant measurement of multiple molecules with histopat...

The South Wales regional NET Multidisciplinary Meeting (MDT) discusses patients on a monthly basis. The European Neuroendocrine Tumour Society (ENETS) have guidance on expected pathology input into a NET MDT service. We assessed pathology reports submitted and discussed in 2016 for compliance with ENETS criteria, and determined the time from pathology reporting to MDT discussion. 117 patients had pathology submitted for review in 2016 and were assessed by one specialist NET pa...